{"id":55,"date":"2013-09-13T21:41:10","date_gmt":"2013-09-13T21:41:10","guid":{"rendered":"http:\/\/williamslab.wordpress.ncsu.edu\/?page_id=55"},"modified":"2025-08-26T19:36:31","modified_gmt":"2025-08-26T19:36:31","slug":"research-2","status":"publish","type":"page","link":"https:\/\/williamslab.wordpress.ncsu.edu\/","title":{"rendered":"Natural Product Synthetic Biology"},"content":{"rendered":"\n\n\n\n\n<p>We are developing a genes-to-molecules synthetic biology pipeline for the synthesis, diversification, and discovery of natural products for drug discovery. We are interested in (1) how natural products are biosynthesized in Nature, (2) how to reprogram natural product biosynthesis to make new analogues, and (3) structure-function relationship studies of biologically active natural products.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/williamslab.wordpress.ncsu.edu\/?attachment_id=354\" rel=\"attachment wp-att-354\"><img loading=\"lazy\" decoding=\"async\" width=\"720\" height=\"405\" src=\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2013\/09\/Slide1.jpg\" alt=\"Slide1\" class=\"wp-image-354\" srcset=\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2013\/09\/Slide1.jpg 720w, https:\/\/williamslab.wordpress.ncsu.edu\/files\/2013\/09\/Slide1-300x169.jpg 300w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/a><\/figure>\n\n\n\n<p>&nbsp;<\/p>\n\n\n<div class=\"ncst-split-container wp-block-ncst-split-container\">\n    \n  <\/div>\n\n\n<div class=\"ncst-labeled-section wp-block-ncst-featured-content ncst-featured-content is-card-style layout-three-column\">\n  <div class=\"ncst-labeled-section__background\">\n    <div class=\"ncst-labeled-section__container\">\n               <div class=\"ncst-labeled-section__header\">\n                      <h2 class=\"ncst-labeled-section__heading\">Main RESEARCH AREAS<\/h2>\n                            <\/div>\n            <div class=\"ncst-labeled-section__content\">\n        \n<div class=\"wp-block-ncst-featured-content\"><a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/williamslab.wordpress.ncsu.edu\/?page_id=840\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Terpene Synthetic Biology<\/h3>\n              \n\n      \n              <p class=\"content-card__cta\"><span class=\"text\">Read more<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/williamslab.wordpress.ncsu.edu\/?page_id=853\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Polyketide Synthetic Biology<\/h3>\n              \n\n      \n              <p class=\"content-card__cta\"><span class=\"text\">Read more<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n\n\n<a\n    class=\"ncst-content-card wp-block-ncst-content-card with-cta\"\n    href=\"https:\/\/williamslab.wordpress.ncsu.edu\/?page_id=859\"\n  >\n  \n    \n    <div class=\"content-card__text-container\">\n      \n                        <h3 class=\"content-card__headline\">Biosensor-Guided Engineering<\/h3>\n              \n\n      \n              <p class=\"content-card__cta\"><span class=\"text\">Read more<\/span><span class=\"arrow-indicator\"><svg class=\"wolficon wolficon-arrow-right-bold\" role=\"img\"  aria-hidden=\"true\">\n\t\t\t\n\t\t\t<use xlink:href=\"#wolficon-arrow-right-bold\">\n\t\t<\/svg><\/span><\/p>\n          <\/div>\n\n  <\/a>\n<\/div>\n\n              <\/div>\n    <\/div>\n  <\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are developing a genes-to-molecules synthetic biology pipeline for the synthesis, diversification, and discovery of natural products for drug discovery. We are interested in (1) how natural products are biosynthesized in Nature, (2) how to reprogram natural product biosynthesis to make new analogues, and (3) structure-function relationship studies of biologically active natural products. &nbsp;<\/p>\n","protected":false},"author":767,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"views\/homepage.blade.php","meta":{"_acf_changed":false,"ncst_dynamicHeaderBlockName":"ncst\/split-header","ncst_dynamicHeaderData":"{\"backgroundColor\":\"red_400\",\"imageID\":834,\"imageURL\":\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2025\/08\/IMG_0500-1-scaled.jpg\",\"pageIntro\":\"Reprogramming the chemistry of life\",\"imageAlt\":\"\"}","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"class_list":["post-55","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/pages\/55","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/users\/767"}],"replies":[{"embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=55"}],"version-history":[{"count":9,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/pages\/55\/revisions"}],"predecessor-version":[{"id":864,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/pages\/55\/revisions\/864"}],"wp:attachment":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}