{"id":614,"date":"2019-01-25T02:52:57","date_gmt":"2019-01-25T02:52:57","guid":{"rendered":"https:\/\/williamslab.wordpress.ncsu.edu\/?p=614"},"modified":"2019-03-15T20:24:51","modified_gmt":"2019-03-15T20:24:51","slug":"614","status":"publish","type":"post","link":"https:\/\/williamslab.wordpress.ncsu.edu\/?p=614","title":{"rendered":"New paper in the J Am Chem Soc!"},"content":{"rendered":"<p>In a <a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/jacs.8b10521\">new paper in JACS<\/a> by recent graduate Edward Kalkreuter (now a postdoc at Scripps, Florida), the synthetic scope of a polyketide synthase was expanded by engineering the incorporation of consecutive extender unit substrates. Unexpected downstream bottlenecks were also revealed, identifying new targets for enzyme engineering.<\/p>\n<p><a href=\"https:\/\/williamslab.wordpress.ncsu.edu\/?attachment_id=617\" rel=\"attachment wp-att-617\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-617\" src=\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2019\/01\/graphical-abstract-1-600x300.jpg\" alt=\"\" width=\"600\" height=\"300\" srcset=\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2019\/01\/graphical-abstract-1-600x300.jpg 600w, https:\/\/williamslab.wordpress.ncsu.edu\/files\/2019\/01\/graphical-abstract-1-768x384.jpg 768w, https:\/\/williamslab.wordpress.ncsu.edu\/files\/2019\/01\/graphical-abstract-1-1200x600.jpg 1200w, https:\/\/williamslab.wordpress.ncsu.edu\/files\/2019\/01\/graphical-abstract-1-500x250.jpg 500w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a new paper in JACS by recent graduate Edward Kalkreuter (now a postdoc at Scripps, Florida), the synthetic scope of a polyketide synthase was expanded by engineering the incorporation of consecutive extender unit substrates. Unexpected downstream bottlenecks were also revealed, identifying new targets for enzyme engineering.<\/p>\n","protected":false},"author":767,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ncst_dynamicHeaderBlockName":"","ncst_dynamicHeaderData":"","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"categories":[8],"tags":[],"class_list":["post-614","post","type-post","status-publish","format-standard","hentry","category-lab-news"],"displayCategory":null,"acf":{"ncst_posts_meta_modified_date":null},"_links":{"self":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts\/614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/users\/767"}],"replies":[{"embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=614"}],"version-history":[{"count":4,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts\/614\/revisions"}],"predecessor-version":[{"id":634,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts\/614\/revisions\/634"}],"wp:attachment":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}