{"id":676,"date":"2020-04-14T15:03:13","date_gmt":"2020-04-14T15:03:13","guid":{"rendered":"https:\/\/williamslab.wordpress.ncsu.edu\/?p=676"},"modified":"2020-04-14T15:03:13","modified_gmt":"2020-04-14T15:03:13","slug":"sime-synthetic-insight-based-macrolide-enumerator-to-generate-the-v1b-library-of-1-billion-macrolides","status":"publish","type":"post","link":"https:\/\/williamslab.wordpress.ncsu.edu\/?p=676","title":{"rendered":"SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides"},"content":{"rendered":"<p>Excited to announce our latest publication and collaboration with the Fourches group in the\u00a0NC State Chemistry, \u201c<a href=\"https:\/\/jcheminf.biomedcentral.com\/articles\/10.1186\/s13321-020-00427-6\">SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides<\/a>\u201d. This advance allows in silico libraries of macrolides to be constructed based on the knowledge of polyketide biosynthesis. It\u2019s a first step towards the generation of new bioactive macrolides by combining synthetic biology and computational chemistry.<\/p>\n<p><a href=\"https:\/\/williamslab.wordpress.ncsu.edu\/?attachment_id=677\" rel=\"attachment wp-att-677\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-medium wp-image-677\" src=\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2020\/04\/13321_2020_427_Figa_HTML-600x265.png\" alt=\"\" width=\"600\" height=\"265\" srcset=\"https:\/\/williamslab.wordpress.ncsu.edu\/files\/2020\/04\/13321_2020_427_Figa_HTML-600x265.png 600w, https:\/\/williamslab.wordpress.ncsu.edu\/files\/2020\/04\/13321_2020_427_Figa_HTML-500x221.png 500w, https:\/\/williamslab.wordpress.ncsu.edu\/files\/2020\/04\/13321_2020_427_Figa_HTML.png 685w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Excited to announce our latest publication and collaboration with the Fourches group in the\u00a0NC State Chemistry, \u201cSIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides\u201d. This advance allows in silico libraries of macrolides to be constructed based on the knowledge of polyketide biosynthesis. It\u2019s a first step towards the generation&hellip;<\/p>\n","protected":false},"author":767,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"ncst_dynamicHeaderBlockName":"","ncst_dynamicHeaderData":"","ncst_content_audit_freq":"","ncst_content_audit_date":"","ncst_content_audit_display":false,"ncst_backToTopFlag":"","footnotes":""},"categories":[8],"tags":[],"class_list":["post-676","post","type-post","status-publish","format-standard","hentry","category-lab-news"],"displayCategory":null,"acf":{"ncst_posts_meta_modified_date":null},"_links":{"self":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts\/676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/users\/767"}],"replies":[{"embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=676"}],"version-history":[{"count":1,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts\/676\/revisions"}],"predecessor-version":[{"id":678,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=\/wp\/v2\/posts\/676\/revisions\/678"}],"wp:attachment":[{"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=676"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/williamslab.wordpress.ncsu.edu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}