Thrilled to share our latest review article, “Transcription factor-based biosensors: A molecular-guided approach for natural product engineering”, with Melissa Mitchler, Jessie Garcia, and Nichole Montero. Nice work everybody!

Excited to share our comprehensive review on isoprenoid synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis at JIMB! Congrats to Anuran Kumar Gayen, Alexandra Malico, and Miles Calzini on this team effort!

Thrilled to share our review article on synthetic biology enabling access to designer polyketides with graduate students Alexandra Malico & Lindsay Nichols!

“Polyketide synthases are multi-domain enzymes that catalyze the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions.”

Grateful for the opportunity along with Anuran Kumar Gayen and Lindsay Nichols to discuss Ramon Gonzalez’s excellent Nature Catalysis research article on artificial polyketide biosynthesis.

See Ramon’s article at https://lnkd.in/dn-sEqC and our News & Views piece at https://rdcu.be/b5F53.

Thrilled to announce that grad student Melissa Mitchler will be supported by an NIH NC State Molecular Biotechnology Training Program Fellowship! Congratulations, Melissa! This is our third graduate student to be supported by this program in the last five years.

Learn more about the program here.

MacrolactoneDB is a central repository of macrolactones and their bioactivities. It enables machine learning to inform synthetic biology and medicinal chemistry efforts for designing new/better drugs. Our new paper in Nature Scientific Reports is the result of a collaboration with Phyo Phyo Kyaw Zin and Sean Ekins (Collaborations Pharmaceuticals).