Publications

26. Ladner C, Williams GJ. “Harnessing natural product assembly lines: structure, promiscuity, and engineering“. J Ind Microbial Biotechnol, DOI 10.1007/s10295-015-1704-8.

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25. Ye Z, Williams GJ. “Mapping a ketosynthase:acyl carrier protein binding interface via unnatural amino acid-mediated photocrosslinking“. Biochemistry, 2015, 53, 7494.

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24. Randall S, Koryakina I, Williams GJ, Muddiman DC. “Evaluating nonpolar surface area and LC-MS response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis”, Rapid Commun Mass Spectrom, 2014, 28, 2511.

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23. Walsh S, Gardner L, Deiters A, Williams GJ. “Intracellular light-activation of riboswitch activity“. ChemBioChem, 2014, 15, 1346.

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22. Ye Z, Musiol EM, Weber T, Williams GJ. “Reprogramming acyl carrier protein interactions of an extender unit promiscuous trans-acyltransferase“. Chem Biol, 2014, 21, 636.

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21. Williams GJ. “Engineering polyketide synthases and non-ribosomal peptide synthetases”. Curr Opin Struct Biol, 2013, 23, 603. pdf

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20. Koryakina I, McArthur JB, Draelos, M, Randall S, Muddiman D, Williams GJ. “Reprogramming the biosynthesis of natural products by directed evolution”. Developments in Biotechnology and Bioprocessing, 2013, 9, 147-63.

19. Koryakina I, McArthur JB, Draelos MD, Williams GJ. “Promiscuity of a Modular Polyketide Synthase Towards Natural and Non-Natural Extender Units”. Org Biomol Chem, 2013, 11, 4449-4458. pdf

OBC covercover artwork in Org Biomol Chem

18. Koryakina I, McArthur J, Randall S, Draelos MM, Musiol EM, Muddiman DC, Weber T, Williams GJ. “Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetases”. ACS Chem Biol, 2013; 8, 200-208.Koryakina Graphical Abstract

17. McArthur J, & Williams GJ. “Engineering Glycosyltransferases”. In The Protein Engineering Handbook, Ed. Stefan Lutz, Wiley-VCH, Weinheim, 2012, Vol 3, 303-326.

16. Ye Z, Desai H, Bair M, Williams GJ. “A novel photocrosslinking assay for reporting protein interactions in polyketide and fatty acid synthases”. Mol BioSys, 2011, 7, 3152-3156. pdf

15. Koryakina I, Williams GJ. “Mutant malonyl-CoA synthetases for polyketide extender unit generation”. ChemBioChem, 2011, 12, 2289-2293. pdf

chembiochemcovercover artwork in ChemBioChem

14. Parajuli N, Williams GJ.  “A high-throughput screen for directed evolution of aminocoumarin amide synthetases”. Anal Biochem, 2011; 419: 61-66. pdf

13. Koryakina I, Neville J, Nonaka K, van Lanen S, Williams GJ. “A high-throughput screen for directed evolution of the natural product sulfotransferase LipB”. J Biomol Screening, 2011; 16: 845-851. pdf

Postdoctoral and graduate:

12. Williams GJ, Yang J, Zhang C, Thorson JS. “Recombinant E. coli prototype strains for in vivo glycorandomization”. ACS Chem Biol, 2011, 6, 95-100.

11. Williams GJ, Gantt RW, Thorson JS. (2008) “The impact of enzyme engineering upon natural product glycodiversification”. Curr Opin Chem Biol, 12, 556-564.

10. Gantt RW, Goff RD, Williams GJ, Thorson JS. “Probing the aglycone promiscuity of an engineered glycosyltransferase”. Angew Chemie Int Ed, 2008, 47, 8889-8892.

9. Williams GJ, Zhang C, Goff R, Thorson JS. “Optimization of a natural product glycosyltransferase for glycorandomization of novobiocin”. Chem Biol, 2008, 15, 393-401.

8. Williams GJ, Thorson JS. “A high-throughput fluorescence-based glycosyltransferase screen and its application in directed evolution”. Nat Protocols, 2008, 3, 357-362.

7. Williams GJ, Zhang C, Thorson JS. “Expanding the promiscuity of a natural product glycosyltransferase by directed evolution”. Nat Chem Biol, 2007, 3, 657-662.

6. Williams GJ, Woodall T, Farnsworth LM, Nelson A, Berry A. “Creation of a pair of stereochemically complementary biocatalysts”. J Am Chem Soc, 2006, 128, 16238-47.

5. Williams GJ, Woodhall T, Nelson A, Berry A. “Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics”. PEDS 2005; 18: 239-246.

4. Woodhall T, Williams GJ, Berry A, Nelson A. “Synthesis of screening substrates for the directed evolution of sialic acid aldolase: Towards tailored enzymes for the preparation of influenza A inhibitor analogues”. Org Biomol Chem, 2005; 3: 1795-1800.

3. Woodhall T, Williams GJ, Berry A, Nelson A. “Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics”. Angew Chemie Int Ed, 2005; 44: 2109-2112.

2. Williams GJ, Nelson A, Berry A. “Directed evolution of enzymes for biocatalysis and the life sciences”. Cell Mol Life Sci, 2004; 61: 3034-3046.

1. Williams GJ, Doman S, Nelson A, Berry A. “Modifying the stereochemical course of an enzyme catalysed reaction by directed evolution”. Proc Natl Acad Sci USA, 2003, 100, 3143-3148.