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Reprogramming the biosynthesis of natural products
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Monthly Archives: January 2019

New paper in the J Am Chem Soc!

Posted on January 25, 2019 by gjwillia

In a new paper in JACS by recent graduate Edward Kalkreuter (now a postdoc at Scripps, Florida), the synthetic scope of a polyketide synthase was expanded by engineering the incorporation of consecutive extender unit substrates. Unexpected downstream bottlenecks were also revealed, identifying new targets for enzyme engineering.

Posted in Lab News by gjwillia

An artificial pathway for isoprenoid biosynthesis

Posted on January 16, 2019 by gjwillia

Nature makes isoprenoids via two lengthy routes that are difficult to engineer. In a new publication in ACS Synthetic Biology, Sean Lund and Rachael Hall describe using synthetic biology to develop a third route that is just 2-enzymes long, easy to engineer, and is highly versatile.  

Posted in Lab News by gjwillia

GLBT Advocate 2020-21

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

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Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

Follow Us!

Follow Us on FacebookFollow Us on TwitterFollow Us on InstagramFollow Us on LinkedInFollow Us on Google+

Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

RSS Recent Publications

  • Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics
  • Protein engineering for natural product biosynthesis and synthetic biology applications
  • Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
  • Transcription factor-based biosensors: a molecular-guided approach for natural product engineering
  • Correction to: Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids
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