Williams Lab @NC State

Reprogramming the biosynthesis of natural products

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Dept of Chemistry

Monthly Archives: November 2020

Student wins poster presentation in an e-symposium

Posted on November 3, 2020 by akgayen

Congratulations to Zhongtian Zhang for the award-winning poster at the Leo W. Parks Lectureship e-symposium!

Posted in Conferences and Meetings, Lab News, NCSU by akgayen

GLBT Advocate 2020-21

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

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Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

Follow Us!

Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

Recent Publications

Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation
Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative
Directed Evolution of a Macrolide-Sensing Transcription Factor Biosensor for the Detection of Macrolactone Aglycones via "Effector Walking" and Efflux Pump Deletion
Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units
Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides

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