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Reprogramming the biosynthesis of natural products
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Monthly Archives: April 2017

Our collaborative work is featured as a journal cover at ACS Synthetic Biology!

Posted on April 7, 2017 by gjwillia

Our collaborative work with Tilmann Weber and Sang Yup Lee on using a promiscuous enzyme and “click” chemistry to make new antibiotics is featured as the journal cover at ACS Synthetic Biology!

Posted in Lab News by gjwillia

Students win poster prizes at international conference!

Posted on April 7, 2017 by gjwillia

Congratulations to Samantha Meiser Carpenter and Edward Kalkreuter for winning 1st and 3rd place poster prizes, respectively, at the Synthetic Biology for Natural Products 2017 meeting in Cancun!

Posted in Lab News by gjwillia

GLBT Advocate 2020-21

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

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Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

Follow Us!

Follow Us on FacebookFollow Us on TwitterFollow Us on InstagramFollow Us on LinkedInFollow Us on Google+

Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

RSS Recent Publications

  • Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation
  • Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative
  • Directed Evolution of a Macrolide-Sensing Transcription Factor Biosensor for the Detection of Macrolactone Aglycones via "Effector Walking" and Efflux Pump Deletion
  • Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units
  • Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides
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