Williams Lab @NC State
Reprogramming the biosynthesis of natural products

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← SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides

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By gjwillia | Published April 14, 2020 | Full size is 685 × 303 pixels

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

RSS Recent Publications

  • Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics
  • Protein engineering for natural product biosynthesis and synthetic biology applications
  • Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
  • Transcription factor-based biosensors: a molecular-guided approach for natural product engineering
  • Correction to: Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids
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