Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli

Our latest paper in ACS Synthetic Biology describes the first genetically-encoded biosensor for detection of polyketide synthase extender units in cells. Because the biosensor is genetically encoded, the cell makes all of the necessary components and the entire system can be subjected to directed evolution. A biosensor for detection of various acyl-CoA’s will help synthetic biology approaches for sustainable production of natural products in microbes.