Excited to announce our latest publication and collaboration with the Fourches group in the NC State Chemistry, “SIME: synthetic insight-based macrolide enumerator to generate the V1B library of 1 billion macrolides”. This advance allows in silico libraries of macrolides to be constructed based on the knowledge of polyketide biosynthesis. It’s a first step towards the generation of new bioactive macrolides by combining synthetic biology and computational chemistry.
