images_medium_sb1c00151_0009 | Williams Lab @NC State

Williams Lab @NC State

Reprogramming the biosynthesis of natural products

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images_medium_sb1c00151_0009

By gjwillia | Published September 24, 2023 | Full size is 500 × 265 pixels

Isoprenoid summary

cbic202300386-toc-0001-m

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

Recent Publications

Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation
Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative
Directed Evolution of a Macrolide-Sensing Transcription Factor Biosensor for the Detection of Macrolactone Aglycones via "Effector Walking" and Efflux Pump Deletion
Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units
Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides

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