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Reprogramming the biosynthesis of natural products
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Publication in ChemBioChem

Posted on September 24, 2023 by gjwillia

I’m delighted to share our review article by graduate student Tad Paulsel on the chemoenzymatic synthesis of polyketides. Thanks to ChemBioChem for making this a VIP article and an Editors Choice Spotlight at ChemEurope.

Posted in Lab News by gjwillia
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GLBT Advocate 2020-21

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

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We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

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Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

Follow Us!

Follow Us on FacebookFollow Us on TwitterFollow Us on InstagramFollow Us on LinkedInFollow Us on Google+

Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

 

 

Join Us!

We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

Funding

RSS Recent Publications

  • Engineering of a Malonyl-CoA Ligase for Production of Fluorinated Polyketide Extender Units
  • Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides
  • Current State-of-the-Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products
  • Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics
  • Protein engineering for natural product biosynthesis and synthetic biology applications
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