graphical abstract | Williams Lab @NC State

Williams Lab @NC State

Reprogramming the biosynthesis of natural products

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graphical abstract

By gjwillia | Published November 28, 2018 | Full size is 362 × 262 pixels

Accessing non-natural small molecules via synthetic biology

The Williams Lab uses a combination of enzyme engineering, metabolic engineering, microbiology, synthetic biology, and organic chemistry, to access various non-natural small molecules and natural products for drug discovery and chemical biology.

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Affiliations

Prof. Williams is a member of the Comparative Medicine Institute at NC State, the BIT Program Training Faculty, the Microbiology Training Faculty, and the Genomic Sciences Initiative Training Faculty.

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We are always looking for talented undergraduates, graduates, and postdocs to join the group! Please contact Gavin Williams for more details. Review our group brochure Williams Lab Brochure 2020

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Recent Publications

Current State-of-the-Art Toward Chemoenzymatic Synthesis of Polyketide Natural Products
Development of Genetically Encoded Biosensors for Reporting the Methyltransferase-Dependent Biosynthesis of Semisynthetic Macrolide Antibiotics
Protein engineering for natural product biosynthesis and synthetic biology applications
Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
Transcription factor-based biosensors: a molecular-guided approach for natural product engineering

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